Holes in the heart: understanding PFO, ASD, and stroke risk

A person holds a detailed anatomical model of a human heart in one hand whilst pointing to a specific part with a wooden stick against a blue background.

Experiencing a stroke without identifiable risk factors is a uniquely distressing clinical scenario, particularly for younger individuals who would not typically be considered at high cardiovascular risk. When routine investigations fail to reveal a clear cause, the diagnosis of a cryptogenic stroke (stroke without a clear cause) introduces profound uncertainty about recurrence and long-term health. […]