Dr A A McLeod Research Publications

1. Schott GD, McLeod AA, Jewitt DE. Cardiac arrhythmias that masquerade as epilepsy. Br Med J 1977; 1:1454-7.

2. McLeod AA, Jewitt DE. The role of 24 hour ambulatory electrocardiographic monitoring in a district general hospital. Br Med J 1978; 1:1197-9.

3. Bibra H von, Castro L, Autenrieth G, McLeod AA, Gurland HJ. The effects of arteriovenous shunts on cardiac function in renal dialysis patients - an echocardiographic evaluation. Clin Nephrol 1978; 9:205-9.

4. Cove-Smith JR, McLeod AA, Blamey RN, Knapp MS, Reeves WG, Wilson CB. Transplantation, immunosuppression and plasmapheresis in Goodpasture’s syndrome. Clin Nephrol 1978; 9:126-8.

5. McLeod AA, Jennings KP, Townsend ER. Near fatal puerperal thrombosis on Björk-Shiley mitral prosthesis. Br Heart J 1978; 40:934-7.

6. McLeod AA, Kitson D, McComish M, Jewitt DE. The role of 24 hour ambulatory monitoring and quantitative assessment of cardiac arrhythmias. In: ISAM 77, Proceedings of the 2nd International Symposium on Ambulatory Monitoring. Stott FD, Raftery EB, Sleight P, Goulding L, eds. London, Academic Press, 1978:77-84.

7. McLeod AA, Cuddigan BJ, Mahon WE. Chronic haemorrhagic disorder induced by dissecting aneurysm. Eur Heart J 1980; 1:409-11.

8. McLeod AA, Jewitt DE. Treatment of ventricular arrhythmias in the coronary care unit. In: Meksilitiini-Symposiumi. Sarajas HSS, Hartel G, eds. Hameenlinna, Arvi A Karisto Oy: n Kirjapaino, 1981.

9. Metcalfe J, Monaghan M, Fisk C, McLeod A, Richardson P, Jackson G, Jewitt D. Cross-sectional and M-mode echocardiography in the evaluation of patients with infective endocarditis. In: Goedhard WJA, Toutouzas P, eds. Recent Advances in Noninvasive Cardiology. Brussels, Stafleus Scientific Publishing Company, 1981:201-4.

10. McLeod A, Monaghan MJ, Richardson PJ, Jackson G, Jewitt DE. . Cross-sectional and M-mode echocardiography in acute aortic dissection. In: Goedhard WJA, Toutouzas P, eds. Recent Advances in Noninvasive Cardiology. Brussels, Stafleus Scientific Publishing Company, 1981:134-8.

11. McLeod AA, Neil-Dwyer G, Meyer CHA, Richardson PL, Cruickshank J, Bartlett J. Cardiac Sequelae of acute head injury. Br Heart J 1982; 47:221-6.

12. Timmis AD, McGonigle RJS, Weston MJ, McLeod AA, McLeod AA, Jackson G, Jewitt DE. The influence of haemodialysis fistulas on circulatory dynamics and left ventricular function. Int J Artificial Organs 1982; 5:101-4.

13. Crofts MAJ, Morgan-Capner P, Sharp JC, McLeod AA, Keates JRW, Jackson G, Hay RJ. Fungal endocarditis in a patient with acute leukaemia treated by valve replacement. Br Med J 1982; 284:574-5.

14. McLeod AA, Monaghan MJ, Richardson PJ, Jackson G, Jewitt DE. Cross-sectional and M-mode echocardiography in the diagnosis of acute aortic dissection: a 5 year experience. Eur Heart J 1983; 4:196-202.

15. McLeod AA, Brown JE, Williams RS, Shand DG. Substrate sparing effect of atenolol compared with propranolol during intensive short term exercise. In: Knuttgen HG, Vogel JA, Poortmans J, eds. Biochemistry of Exercise (Proceedings, Vth International Symposium on the Biochemistry of Exercise, Boston, June 1982). Champaign, IL, 1983, Human Kinetics Publishers: 252-7.

16. Brown JE, McLeod AA, Shand DG. Evidence for cardiac beta2 receptors in humans. Clin Pharmacol Ther 1983; 33:424-8.

17. McLeod AA, Brown JE, Kuhn C, Kitchell BB, Sedor FA, Williams RS, Shand DG. Differentiation of haemodynamic, humoral and metabolic responses to beta1 and beta2 adrenoceptor stimulation in man using atenolol and propranolol. Circulation 1983; 67:1076-84.

18. Verghese C, McLeod AA, Shand DG. A rapid high-performance liquid chromatographic method for the measurement of atenolol in plasma using UV detection. J Chromatogr 1983; 275:367-76.

19. McLeod AA, Stiles GL, Shand DG. Demonstration of beta-adrenoceptor blockade by propafenone hydrochloride: clinical pharmacologic, radioligand binding and adenylate cyclase activation studies. J Pharmacol Exp Ther 1984; 228:461-6.

20. McLeod AA, Brown JE, Kitchell BB, Sedor FA, Kuhn C, Williams RS, Shand DG. Hemodynamic and metabolic responses to exercise after alpha1, beta1, and non-selective adrenoceptor blockade in man. Am J Med 1984; 76 (2A):97-100.

21. McLeod AA, Brown JE, Kitchell BB, Sedor FA, Kuhn C, Shand DG, Williams RS. Hemodynamic and metabolic responses to exercise after adrenoceptor blockade in humans. J Appl Physiol: Respirat Environ Exercise Physiol 1984; 56:716-22.

22. McLeod AA, Kraus WE, Williams RS. Effects of beta1-selective and non-selective beta-adrenoceptor blockade during exercise conditioning in healthy adults. Am J Cardiol 1984; 53:1656-61.

23. McLeod AA, Knopes KD, Shand DG, Williams RS. Beta1-selective and non selective beta-adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during exercise. Br J Clin Pharmacol 1985; 19:13-20.

24. Timmis AD, Smyth P, Monaghan M, Walker L, Daly K, McLeod AA, Jewitt DE. Milrinone in heart failure. Acute effects on left ventricular systolic function and myocardial metabolism. Br Heart J 1985; 54:36-41.

25. Brown JE, McLeod AA, Shand DG. In support of cardiac chronotropic beta2 adrenoceptors. Am J Cardiol 1986; 57:11F-16F.

26. McLeod AA, Marjot R, Monaghan MJ, Hugh-Jones P, Jackson G. Chronic cardiac toxicity after inhalation of 1,1,1-trichloroethane. Br Med J 1987; 294:727-9.

27. McLeod AA. Shades of Richard Asher? Br J Radiol 1988; 61:346.

28. Grenfell A, Monaghan M, Watkins PJ, McLeod AA. Cardiac hypertrophy in diabetic nephropathy: an echocardiographic study. Diabetic Medicine 1988; 5:840-4.

29. Marjot R, McLeod AA. Chronic non-neurological toxicity from volatile substance abuse. Human Toxicol 1989; 8:301-6.

30. McLeod AA, Thorogood S, Barnett S. Torsades de pointes complicating treatment with terodiline. BMJ 1991; 302:1469

31. McLeod AA. Health gains from invasive and interventional procedures in coronary artery disease: review of evidence and current UK trends. Coronary Health Care 1998; 2:129-139.

32. Garg A, Ogilvie BC, McLeod AA. Anomalous origin of the left coronary artery from the non-coronary sinus of Valsalva. Heart 2000; 84: 136.

33. Sharma R, McLeod AA. Cardiac rehabilitation after coronary artery bypass graft surgery: its effect on ischaemia, functional capacity, and a multivariate index of prognosis. Coronary Health Care 2001; 5:189-193.

34. Sharma R, McLeod AA. Pulmonary hypertension: a rare but serious complication of ventriculoatrial shunts. Hospital Medicine 2004; 65:242-3.

35. McLeod AA, Jokhi PP. Pacemaker induced ventricular fibrillation in coronary care units. BMJ 2004;328:1249-1250.

COMMISSIONED ARTICLES:

1. McLeod AA, Shand DG. Atenolol: a long acting beta1-adrenoceptor antagonist. Ann Intern Med 1982; 96:244-5.

2. McLeod AA, Chamberlain DA. Recent advances in beta-blocking therapy: clinical indications and pharmacology. In: Goodwin JF, Yu PN, eds. Progress in Cardiology 13, 1985; Philadelphia, Lea and Febiger:145-78.

3. McLeod AA, Jewitt DE. Drug treatment of primary pulmonary hypertension. Drugs 1986; 31:177-84.

4. McLeod AA, Jewitt DE. Drug treatment of primary pulmonary hypertension. Hospital Therapeutics (New Zealand) 1986; 3 (4):25-39.

5. All echocardiographic illustrations in: Armstrong P, Wastie ML. Diagnostic imaging. 2nd ed, 1987. Oxford, Blackwell Scientific Publications.

6. The timing of heart valve replacement. In: Jackson G, ed. Difficult Cardiology. Martin Dunitz Limited, London. 1990.

7. A report of a working group of the BCS: Cardiology in the District Hospital. Br Heart J 1994; 72:303-8 (Primary Author).

8. London Implementation Group. Report of the Cardiac Specialty Review Group. London: HMSO, 1993 (Contributory Author).

9. McLeod A, Coats AJS. Medical aspects of cardiac rehabilitation. In: Coats A, McGee H, Stokes H, Thompson D, eds. BACR Guidelines for Cardiac Rehabilitation: 40-55. Oxford: Blackwell Science Ltd., 1995.

10. BCS Working Group. The changing interface between district hospital cardiology and the major cardiac centres. Heart 1997; 78:519-523 (Contributory Author).

11. McLeod A. The Medical Component. In: Thompson DR, Bowman GS, de Bono DP, Hopkins A, eds. Cardiac Rehabilitation Guidelines and Audit Standards. Royal College of Physicians of London, 1997: 9-19.

12. McLeod AA. Cardiac Rehabilitation: does it work? Update 1998; 56: 759-766.

13. Cardiac Rehabilitation. Brodie D, ed. British Association for Cardiac Rehabilitation. Colourways Ltd. 2000 (wrote the clinical component including developing the clinical scenario approach).

14. McLeod AA. Later management of documented ischaemic heart disease: secondary prevention and rehabilitation. British Medical Bulletin 2001; 59:113-133.

15. Wood D, McLeod A, Davis M, Miles A, editors. The effective management of secondary prevention. London, Aesculapius Medical Press, 2002 (including chapter).

16. McLeod AA. Constructing an Exercise Programme. Heart and Metabolism 2005; 26:20-22.

PUBLICATIONS FROM MULTICENTRE TRIALS AS PARTICIPANT:

1. The Xamoterol in severe heart failure study group. Xamoterol in severe heart failure. Lancet 1990; 336:1-6.

2. The Total Ischaemic Burden European Trial (TIBET). Effects of atenolol, nifedipine SR and their combination on the exercise test and the total ischaemic burden in 608 patients with stable angina. Fox KM, Mulcahy D, Findlay I, Ford I, Dargie HJ on behalf of the TIBET Study Group. Eur Heart J 1996; 17: 96-103.

ABSTRACTS:

I have presented and published over 30 abstracts at major international meetings. These include: British Cardiac Society, seven times, including the Young Investigator’s Prize; American Heart Association, twice; American College of Cardiology, once; American Federation for Clinical Research, twice; and other major meetings including the Renal Association, and the American Society for Clinical Pharmacology and Therapeutics. The most recent abstracts were presented at the American Academy of Cardiovascular and Pulmonary Rehabilitation meeting in October 1998, the British Cardiac Society in May 1999, and the British Association for Cardiac Rehabilitation, September 2001 (McLeod AA. Cardiac Rehabilitation Research in Borsetshire: a tale of three studies).

Abstracts relevant to Poole Hospital:

Howarth B, Klein G, McLeod A. Comparison of a chest pain clinic with an open access exercise ECG service. Br Heart J 1994 (Suppl). 71:P66

McLeod AA, Armstrong-Klein S, Ellis B, Stringer J, Wright S, Walker G. Are women better than men? Physical conditioning in a cardiac rehabilitation programme in subjects with coronary artery disease. Br Heart J 1993 (Suppl); 69:P54

McLeod AA. Cardiac rehabilitation: effects on fibrinogen and physical fitness complement the actions of lipid-lowering drugs. Journal of Cardiopulmonary Rehabilitation 1998; 18: 367

Sharma R, McLeod AA. Indices of ischaemia and functional capacity in coronary artery disease – relative benefits of cardiac surgery and cardiac rehabilitation. Heart 1999; 81 (Suppl 1) : 48

McLeod AA. Secondary prevention after myocardial infarction. What factors determine treatment? Analysis from 1991-1999. Presented to British Cardiac Society, May 2002. Heart 2002; 87 (Suppl II):42

(Also presented at European Society of Cardiology Working Group in Exercise Physiology and Cardiac Rehabilitation, Leipzig, May 2002).

Foley PWX, Winterton SJ, Radvan JR, Simpson IA, McLeod AA. The impact of pre-hospital thrombolysis in Dorset (Heart supplement, May 2006).