Dr A A McLeod Research Publications
1. Schott GD, McLeod AA, Jewitt DE. Cardiac arrhythmias that masquerade as epilepsy.
Br Med J 1977; 1:1454-7.
2. McLeod AA, Jewitt DE. The role of 24 hour ambulatory electrocardiographic monitoring
in a district general hospital. Br Med J 1978; 1:1197-9.
3. Bibra H von, Castro L, Autenrieth G, McLeod AA, Gurland HJ. The effects of arteriovenous
shunts on cardiac function in renal dialysis patients - an echocardiographic evaluation.
Clin Nephrol 1978; 9:205-9.
4. Cove-Smith JR, McLeod AA, Blamey RN, Knapp MS, Reeves WG, Wilson CB. Transplantation,
immunosuppression and plasmapheresis in Goodpasture’s syndrome. Clin Nephrol 1978;
9:126-8.
5. McLeod AA, Jennings KP, Townsend ER. Near fatal puerperal thrombosis on Björk-Shiley
mitral prosthesis. Br Heart J 1978; 40:934-7.
6. McLeod AA, Kitson D, McComish M, Jewitt DE. The role of 24 hour ambulatory monitoring
and quantitative assessment of cardiac arrhythmias. In: ISAM 77, Proceedings of
the 2nd International Symposium on Ambulatory Monitoring. Stott FD, Raftery EB,
Sleight P, Goulding L, eds. London, Academic Press, 1978:77-84.
7. McLeod AA, Cuddigan BJ, Mahon WE. Chronic haemorrhagic disorder induced by dissecting
aneurysm. Eur Heart J 1980; 1:409-11.
8. McLeod AA, Jewitt DE. Treatment of ventricular arrhythmias in the coronary care
unit. In: Meksilitiini-Symposiumi. Sarajas HSS, Hartel G, eds. Hameenlinna, Arvi
A Karisto Oy: n Kirjapaino, 1981.
9. Metcalfe J, Monaghan M, Fisk C, McLeod A, Richardson P, Jackson G, Jewitt D.
Cross-sectional and M-mode echocardiography in the evaluation of patients with infective
endocarditis. In: Goedhard WJA, Toutouzas P, eds. Recent Advances in Noninvasive
Cardiology. Brussels, Stafleus Scientific Publishing Company, 1981:201-4.
10. McLeod A, Monaghan MJ, Richardson PJ, Jackson G, Jewitt DE. . Cross-sectional
and M-mode echocardiography in acute aortic dissection. In: Goedhard WJA, Toutouzas
P, eds. Recent Advances in Noninvasive Cardiology. Brussels, Stafleus Scientific
Publishing Company, 1981:134-8.
11. McLeod AA, Neil-Dwyer G, Meyer CHA, Richardson PL, Cruickshank J, Bartlett J.
Cardiac Sequelae of acute head injury. Br Heart J 1982; 47:221-6.
12. Timmis AD, McGonigle RJS, Weston MJ, McLeod AA, McLeod AA, Jackson G, Jewitt
DE. The influence of haemodialysis fistulas on circulatory dynamics and left ventricular
function. Int J Artificial Organs 1982; 5:101-4.
13. Crofts MAJ, Morgan-Capner P, Sharp JC, McLeod AA, Keates JRW, Jackson G, Hay
RJ. Fungal endocarditis in a patient with acute leukaemia treated by valve replacement.
Br Med J 1982; 284:574-5.
14. McLeod AA, Monaghan MJ, Richardson PJ, Jackson G, Jewitt DE. Cross-sectional
and M-mode echocardiography in the diagnosis of acute aortic dissection: a 5 year
experience. Eur Heart J 1983; 4:196-202.
15. McLeod AA, Brown JE, Williams RS, Shand DG. Substrate sparing effect of atenolol
compared with propranolol during intensive short term exercise. In: Knuttgen HG,
Vogel JA, Poortmans J, eds. Biochemistry of Exercise (Proceedings, Vth International
Symposium on the Biochemistry of Exercise, Boston, June 1982). Champaign, IL, 1983,
Human Kinetics Publishers: 252-7.
16. Brown JE, McLeod AA, Shand DG. Evidence for cardiac beta2 receptors in humans.
Clin Pharmacol Ther 1983; 33:424-8.
17. McLeod AA, Brown JE, Kuhn C, Kitchell BB, Sedor FA, Williams RS, Shand DG. Differentiation
of haemodynamic, humoral and metabolic responses to beta1 and beta2 adrenoceptor
stimulation in man using atenolol and propranolol. Circulation 1983; 67:1076-84.
18. Verghese C, McLeod AA, Shand DG. A rapid high-performance liquid chromatographic
method for the measurement of atenolol in plasma using UV detection. J Chromatogr
1983; 275:367-76.
19. McLeod AA, Stiles GL, Shand DG. Demonstration of beta-adrenoceptor blockade
by propafenone hydrochloride: clinical pharmacologic, radioligand binding and adenylate
cyclase activation studies. J Pharmacol Exp Ther 1984; 228:461-6.
20. McLeod AA, Brown JE, Kitchell BB, Sedor FA, Kuhn C, Williams RS, Shand DG. Hemodynamic
and metabolic responses to exercise after alpha1, beta1, and non-selective adrenoceptor
blockade in man. Am J Med 1984; 76 (2A):97-100.
21. McLeod AA, Brown JE, Kitchell BB, Sedor FA, Kuhn C, Shand DG, Williams RS. Hemodynamic
and metabolic responses to exercise after adrenoceptor blockade in humans. J Appl
Physiol: Respirat Environ Exercise Physiol 1984; 56:716-22.
22. McLeod AA, Kraus WE, Williams RS. Effects of beta1-selective and non-selective
beta-adrenoceptor blockade during exercise conditioning in healthy adults. Am J
Cardiol 1984; 53:1656-61.
23. McLeod AA, Knopes KD, Shand DG, Williams RS. Beta1-selective and non selective
beta-adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during
exercise. Br J Clin Pharmacol 1985; 19:13-20.
24. Timmis AD, Smyth P, Monaghan M, Walker L, Daly K, McLeod AA, Jewitt DE. Milrinone
in heart failure. Acute effects on left ventricular systolic function and myocardial
metabolism. Br Heart J 1985; 54:36-41.
25. Brown JE, McLeod AA, Shand DG. In support of cardiac chronotropic beta2 adrenoceptors.
Am J Cardiol 1986; 57:11F-16F.
26. McLeod AA, Marjot R, Monaghan MJ, Hugh-Jones P, Jackson G. Chronic cardiac toxicity
after inhalation of 1,1,1-trichloroethane. Br Med J 1987; 294:727-9.
27. McLeod AA. Shades of Richard Asher? Br J Radiol 1988; 61:346.
28. Grenfell A, Monaghan M, Watkins PJ, McLeod AA. Cardiac hypertrophy in diabetic
nephropathy: an echocardiographic study. Diabetic Medicine 1988; 5:840-4.
29. Marjot R, McLeod AA. Chronic non-neurological toxicity from volatile substance
abuse. Human Toxicol 1989; 8:301-6.
30. McLeod AA, Thorogood S, Barnett S. Torsades de pointes complicating treatment
with terodiline. BMJ 1991; 302:1469
31. McLeod AA. Health gains from invasive and interventional procedures in coronary
artery disease: review of evidence and current UK trends. Coronary Health Care 1998;
2:129-139.
32. Garg A, Ogilvie BC, McLeod AA. Anomalous origin of the left coronary artery
from the non-coronary sinus of Valsalva. Heart 2000; 84: 136.
33. Sharma R, McLeod AA. Cardiac rehabilitation after coronary artery bypass graft
surgery: its effect on ischaemia, functional capacity, and a multivariate index
of prognosis. Coronary Health Care 2001; 5:189-193.
34. Sharma R, McLeod AA. Pulmonary hypertension: a rare but serious complication
of ventriculoatrial shunts. Hospital Medicine 2004; 65:242-3.
35. McLeod AA, Jokhi PP. Pacemaker induced ventricular fibrillation in coronary
care units. BMJ 2004;328:1249-1250.
COMMISSIONED ARTICLES:
1. McLeod AA, Shand DG. Atenolol: a long acting beta1-adrenoceptor antagonist. Ann
Intern Med 1982; 96:244-5.
2. McLeod AA, Chamberlain DA. Recent advances in beta-blocking therapy: clinical
indications and pharmacology. In: Goodwin JF, Yu PN, eds. Progress in Cardiology
13, 1985; Philadelphia, Lea and Febiger:145-78.
3. McLeod AA, Jewitt DE. Drug treatment of primary pulmonary hypertension. Drugs
1986; 31:177-84.
4. McLeod AA, Jewitt DE. Drug treatment of primary pulmonary hypertension. Hospital
Therapeutics (New Zealand) 1986; 3 (4):25-39.
5. All echocardiographic illustrations in: Armstrong P, Wastie ML. Diagnostic imaging.
2nd ed, 1987. Oxford, Blackwell Scientific Publications.
6. The timing of heart valve replacement. In: Jackson G, ed. Difficult Cardiology.
Martin Dunitz Limited, London. 1990.
7. A report of a working group of the BCS: Cardiology in the District Hospital.
Br Heart J 1994; 72:303-8 (Primary Author).
8. London Implementation Group. Report of the Cardiac Specialty Review Group. London:
HMSO, 1993 (Contributory Author).
9. McLeod A, Coats AJS. Medical aspects of cardiac rehabilitation. In: Coats A,
McGee H, Stokes H, Thompson D, eds. BACR Guidelines for Cardiac Rehabilitation:
40-55. Oxford: Blackwell Science Ltd., 1995.
10. BCS Working Group. The changing interface between district hospital cardiology
and the major cardiac centres. Heart 1997; 78:519-523 (Contributory Author).
11. McLeod A. The Medical Component. In: Thompson DR, Bowman GS, de Bono DP, Hopkins
A, eds. Cardiac Rehabilitation Guidelines and Audit Standards. Royal College of
Physicians of London, 1997: 9-19.
12. McLeod AA. Cardiac Rehabilitation: does it work? Update 1998; 56: 759-766.
13. Cardiac Rehabilitation. Brodie D, ed. British Association for Cardiac Rehabilitation.
Colourways Ltd. 2000 (wrote the clinical component including developing the clinical
scenario approach).
14. McLeod AA. Later management of documented ischaemic heart disease: secondary
prevention and rehabilitation. British Medical Bulletin 2001; 59:113-133.
15. Wood D, McLeod A, Davis M, Miles A, editors. The effective management of secondary
prevention. London, Aesculapius Medical Press, 2002 (including chapter).
16. McLeod AA. Constructing an Exercise Programme. Heart and Metabolism 2005; 26:20-22.
PUBLICATIONS FROM MULTICENTRE TRIALS AS PARTICIPANT:
1. The Xamoterol in severe heart failure study group. Xamoterol in severe heart
failure. Lancet 1990; 336:1-6.
2. The Total Ischaemic Burden European Trial (TIBET). Effects of atenolol, nifedipine
SR and their combination on the exercise test and the total ischaemic burden in
608 patients with stable angina. Fox KM, Mulcahy D, Findlay I, Ford I, Dargie HJ
on behalf of the TIBET Study Group. Eur Heart J 1996; 17: 96-103.
ABSTRACTS:
I have presented and published over 30 abstracts at major international meetings.
These include: British Cardiac Society, seven times, including the Young Investigator’s
Prize; American Heart Association, twice; American College of Cardiology, once;
American Federation for Clinical Research, twice; and other major meetings including
the Renal Association, and the American Society for Clinical Pharmacology and Therapeutics.
The most recent abstracts were presented at the American Academy of Cardiovascular
and Pulmonary Rehabilitation meeting in October 1998, the British Cardiac Society
in May 1999, and the British Association for Cardiac Rehabilitation, September 2001
(McLeod AA. Cardiac Rehabilitation Research in Borsetshire: a tale of three studies).
Abstracts relevant to Poole Hospital:
Howarth B, Klein G, McLeod A. Comparison of a chest pain clinic with an open access
exercise ECG service. Br Heart J 1994 (Suppl). 71:P66
McLeod AA, Armstrong-Klein S, Ellis B, Stringer J, Wright S, Walker G. Are women
better than men? Physical conditioning in a cardiac rehabilitation programme in
subjects with coronary artery disease. Br Heart J 1993 (Suppl); 69:P54
McLeod AA. Cardiac rehabilitation: effects on fibrinogen and physical fitness complement
the actions of lipid-lowering drugs. Journal of Cardiopulmonary Rehabilitation 1998;
18: 367
Sharma R, McLeod AA. Indices of ischaemia and functional capacity in coronary artery
disease – relative benefits of cardiac surgery and cardiac rehabilitation. Heart
1999; 81 (Suppl 1) : 48
McLeod AA. Secondary prevention after myocardial infarction. What factors determine
treatment? Analysis from 1991-1999. Presented to British Cardiac Society, May 2002.
Heart 2002; 87 (Suppl II):42
(Also presented at European Society of Cardiology Working Group in Exercise Physiology
and Cardiac Rehabilitation, Leipzig, May 2002).
Foley PWX, Winterton SJ, Radvan JR, Simpson IA, McLeod AA. The impact of pre-hospital
thrombolysis in Dorset (Heart supplement, May 2006).